Individual participant data meta-analyses should not ignore clustering
نویسندگان
چکیده
منابع مشابه
Individual participant data meta-analyses compared with meta-analyses based on aggregate data
BACKGROUND Meta-analyses based on individual participant data (IPD-MAs) allow more powerful and uniformly consistent analyses as well as better characterisation of subgroups and outcomes, compared to those which are based on aggregate data (AD-MAs) extracted from published trial reports. However, IPD-MAs are a larger undertaking requiring greater resources than AD-MAs. Researchers have compared...
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When combining results across related studies, a multivariate meta-analysis allows the joint synthesis of correlated effect estimates from multiple outcomes. Joint synthesis can improve efficiency over separate univariate syntheses, may reduce selective outcome reporting biases, and enables joint inferences across the outcomes. A common issue is that within-study correlations needed to fit the ...
متن کاملIPDMA: Individual Patient/Participant Data Meta-Analysis
In a previous article in KT Update (Dijkers, 2014), the development of meta-analysis (MA) was sketched from (1) meta-analysis of individual study findings (e.g., means and standard deviations, correlations) reported in the literature, to (2) meta-analysis of individual subject data harvested from the published literature, to (3) merging of datasets from multiple studies that share subject popul...
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PURPOSE While individual participant data (IPD) meta-analyses are considered the gold standard for meta-analysis, the feasibility of obtaining IPD may be problematic. METHODS Using data from a previous meta-analysis of 29 studies on exercise in adults with arthritis and other rheumatic diseases, the percentage of studies in which useable IPD was provided was calculated. RESULTS Eight of 29 ...
متن کاملHow individual participant data meta-analyses have influenced trial design, conduct, and analysis
OBJECTIVES To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer. STUDY DESIGN AND SETTING Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses...
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ژورنال
عنوان ژورنال: Journal of Clinical Epidemiology
سال: 2013
ISSN: 0895-4356
DOI: 10.1016/j.jclinepi.2012.12.017